Proposed model to explain the initiation of NOD1- and NOD2-dependent signal transduction.

Endosomes as platforms for NOD-like receptor signaling.

Abstract

The NOD-like receptors (NLRs) were among the first innate immune receptors discovered, yet a clear understanding of the basic principles underlying their mechanisms of action is lacking. Two recent studies provide important cell biological insights into the subcellular sites of NOD1- and NOD2-dependent signaling.

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